MCEMP1 Antibody / Mast cell-expressed membrane protein 1, 100 ug

MCEMP1 antibody detects Mast cell-expressed membrane protein 1, a type I transmembrane protein implicated in immune cell activation and inflammatory signaling. The UniProt recommended name is Mast cell-expressed membrane protein 1 (MCEMP1). This protein is predominantly expressed in mast cells, monocytes, and macrophages, where it may function as a receptor or co-stimulatory molecule regulating immune responses.

Functionally, MCEMP1 antibody identifies a 177-amino-acid membrane glycoprotein featuring a short extracellular region, a single transmembrane domain, and a cytoplasmic tail containing an immunoreceptor tyrosine-based activation motif (ITAM). Upon phosphorylation, MCEMP1 can recruit SYK kinase and other signaling molecules, promoting cytokine production and cell activation.

The MCEMP1 gene is located on chromosome 19q13.4 and is expressed primarily in immune cells of the myeloid lineage, including mast cells, basophils, and macrophages. MCEMP1 expression increases during inflammation, allergic responses, and infection, suggesting a role in innate immune activation. It may also contribute to cytokine cross-talk between immune cells and epithelial barriers.

Pathologically, aberrant MCEMP1 expression is associated with allergic inflammation, asthma, and sepsis. Its upregulation in immune cells correlates with hyperinflammatory states, making it a potential biomarker for inflammatory disorders. Research using MCEMP1 antibody helps clarify its role in immune activation and signaling mechanisms.

MCEMP1 antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect immune cell membrane proteins. NSJ Bioreagents provides MCEMP1 antibody reagents optimized for research in immunology, inflammation, and signal transduction.

Structurally, Mast cell-expressed membrane protein 1 contains a single-pass transmembrane segment and cytoplasmic ITAM motifs that drive downstream kinase signaling. This antibody aids in studies of MCEMP1's potential receptor functions and involvement in immune regulation.