SYT10 Antibody / Synaptotagmin 10, 100 ug

SYT10 antibody detects Synaptotagmin-10, a member of the synaptotagmin family of membrane-trafficking proteins involved in calcium-dependent vesicle exocytosis. The UniProt recommended name is Synaptotagmin-10 (SYT10), with alternate names including Synaptotagmin X and p65. Synaptotagmins act as calcium sensors that regulate synaptic vesicle fusion with the plasma membrane, mediating neurotransmitter and hormone release. SYT10, like other synaptotagmins, contains two C2 domains that bind calcium and phospholipids to trigger vesicle exocytosis.

Functionally, SYT10 antibody identifies a 565-amino-acid protein that plays a role in the regulation of insulin secretion and neuronal exocytosis. SYT10 is unique among synaptotagmins because it is expressed in both neuronal and non-neuronal tissues, including the pancreas and pituitary gland. It is associated with the release of insulin-like growth factor 1 (IGF-1) and other neuropeptides in a calcium-dependent manner. Through its C2A and C2B domains, SYT10 mediates the calcium-triggered docking and fusion of secretory vesicles, ensuring precise timing of exocytosis following intracellular signaling events.

The SYT10 antibody is used to study secretory pathways, vesicular transport, and neuronal communication. In neurons, SYT10 localizes to presynaptic membranes and regulates neurotransmitter release by acting as a Ca2+-sensor for synaptic vesicle fusion. In endocrine cells, it supports hormone secretion by coupling calcium signaling to vesicular exocytosis. Expression of SYT10 is enriched in specific brain regions such as the cortex and cerebellum, reflecting specialized regulatory roles in neurotransmission.

Mutations or dysregulation of SYT10 have been associated with altered synaptic signaling and insulin secretion. The SYT10 gene is located on chromosome 12q21.32 and encodes a protein with two conserved C2 domains responsible for calcium and phospholipid binding. Unlike some synaptotagmins that promote rapid synchronous release, SYT10 is implicated in sustained and asynchronous release events. Research indicates that SYT10 may also participate in neurotrophic signaling and membrane repair processes.

SYT10 antibody applications include western blotting, immunocytochemistry, and confocal microscopy to examine vesicle trafficking, synaptic plasticity, and calcium-triggered secretion. Its use extends to neuroendocrine and pancreatic models where SYT10 mediates regulated exocytosis. NSJ Bioreagents provides this antibody validated for research applications in neuroscience, endocrinology, and cell signaling to investigate vesicular transport and exocytotic mechanisms.