ADAMTS1 Antibody / A disintegrin and metalloproteinase with thrombospondin motifs 1, 100 ug

ADAMTS1 antibody detects A disintegrin and metalloproteinase with thrombospondin motifs 1, a secreted protease involved in extracellular matrix remodeling, angiogenesis, and inflammation. The UniProt recommended name is A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), with alternate names METH1, ADAM-TS1, and protease METH-1. ADAMTS1 belongs to the ADAMTS family of zinc-dependent proteases characterized by metalloprotease, disintegrin-like, and thrombospondin type 1 (TSP-1) domains that coordinate matrix turnover and growth factor regulation.

Functionally, ADAMTS1 antibody recognizes a multi-domain enzyme that cleaves proteoglycans such as aggrecan and versican, controlling tissue remodeling during development, wound healing, and pathological fibrosis. ADAMTS1 also regulates angiogenesis by inhibiting endothelial cell proliferation and migration, in part through sequestration of VEGF signaling. The enzyme is expressed in many tissues including heart, kidney, and placenta, and its upregulation occurs in response to inflammatory cytokines, mechanical stress, and injury. ADAMTS1 participates in ovulation, cardiac morphogenesis, and tumor microenvironment remodeling.

Mutations or dysregulated expression of ADAMTS1 contribute to cardiovascular disease, cancer progression, and arthritis. Studies show reduced ADAMTS1 expression enhances tumor growth by promoting vascularization, whereas overexpression suppresses angiogenesis and metastasis. In the vascular system, ADAMTS1 modulates smooth muscle cell migration and matrix elasticity, maintaining vessel wall integrity. ADAMTS1 antibody is used to evaluate expression patterns and enzymatic activity via immunohistochemistry, zymography, and ELISA assays.

The ADAMTS1 gene, located on chromosome 21q21.3, encodes a 967-amino acid secreted glycoprotein activated by furin cleavage. Post-translational modifications, including glycosylation and proteolytic processing, regulate its localization and activity in the extracellular matrix. Interaction with TIMPs (tissue inhibitors of metalloproteinases) and integrins helps fine-tune its catalytic balance. In development, ADAMTS1 is crucial for follicular rupture during ovulation, kidney branching morphogenesis, and skeletal formation.

By targeting a central ECM protease, the ADAMTS1 antibody enables in-depth study of extracellular remodeling and angiogenic signaling in physiology and pathology. NSJ Bioreagents offers validated antibodies for human, mouse, and rat ADAMTS1 detection suitable for tissue analysis, immunoblotting, and functional proteomics research.