SHD Antibody / SH2 domain-containing adapter protein D, 100 ug

SHD antibody detects SH2 domain-containing adapter protein D, a cytoplasmic adaptor molecule that transduces tyrosine kinase signals controlling cell differentiation, immune activation, and neuronal development. Encoded by the SHD gene on chromosome 4q28.1, this protein contains an SH2 (Src homology 2) domain that recognizes phosphotyrosine motifs and mediates protein-protein interactions within intracellular signaling cascades. SHD acts as a linker between activated receptors and downstream signaling enzymes, contributing to signal amplification and specificity.

Structurally, SHD is a 440-amino-acid protein of approximately 48 kilodaltons featuring a central SH2 domain flanked by low-complexity regions that facilitate interaction with membrane receptors and signaling complexes. It localizes to the cytoplasm and plasma membrane following receptor activation and participates in pathways initiated by growth factors, cytokines, and immune receptors. Through its SH2-mediated binding, SHD recruits kinases and phosphatases that regulate phosphorylation dynamics and cellular response outcomes.

The SHD antibody is widely used in immunology, signal transduction, and neurobiology research to study SH2 domain-mediated signaling, receptor cross-talk, and cytoplasmic adaptor functions. Western blot analysis detects a 48 kilodalton band corresponding to SHD, while immunofluorescence shows diffuse cytoplasmic and membrane-associated staining. This antibody enables detailed examination of signaling network architecture and adaptor-mediated pathway modulation.

Functionally, SHD contributes to the organization of signaling complexes downstream of tyrosine kinases, facilitating rapid response to extracellular cues. It modulates pathways involving MAPK, JAK/STAT, and PI3K signaling cascades, thereby influencing immune activation, synaptic development, and cell fate determination. Dysregulation of SHD expression may alter immune receptor signaling and neuronal differentiation, implicating the protein in both immunological and developmental disorders. The SHD antibody provides a valuable research tool for characterizing intracellular adaptor networks and phosphotyrosine-dependent signaling mechanisms. NSJ Bioreagents validates this antibody for its applications, ensuring specificity and reliability in kinase and receptor signaling research.