SNTB1 Antibody / Beta-1-Syntrophin, 100 ug

SNTB1 antibody detects Beta-1-syntrophin, a cytoskeletal adaptor protein involved in signal transduction, membrane organization, and muscle integrity. Encoded by the SNTB1 gene on chromosome 8q23.1, this protein belongs to the syntrophin family, which binds to dystrophin and associated glycoprotein complexes at the sarcolemma. SNTB1 links signaling molecules to the cytoskeleton, coordinating ion channel localization, receptor clustering, and intracellular signaling in muscle and neuronal tissues.

Structurally, SNTB1 contains PDZ, PH, and SU domains that mediate interactions with ion channels, kinases, and membrane receptors. It associates with the dystrophin complex through its PH domain and serves as a scaffold for signaling proteins such as neuronal nitric oxide synthase (nNOS) and voltage-gated sodium channels. By organizing these proteins at the plasma membrane, SNTB1 maintains muscle membrane stability and signal transduction efficiency.

The SNTB1 antibody is used in muscle biology, neuroscience, and membrane signaling research to study the dystrophin-associated complex and its role in muscular and neurological disorders. Western blot analysis identifies a 60 kilodalton band corresponding to SNTB1, while immunofluorescence reveals sarcolemmal and cytoplasmic staining in muscle fibers and neurons. This antibody provides a critical tool for exploring membrane-associated scaffolding and signaling mechanisms.

Mutations or altered expression of syntrophin family members, including SNTB1, contribute to muscular dystrophy, channelopathies, and synaptic dysfunction. SNTB1 also participates in signaling pathways regulating calcium homeostasis and cytoskeletal remodeling. The SNTB1 antibody supports research into these pathways and their implications in neuromuscular and cardiovascular diseases. NSJ Bioreagents supplies this antibody validated for its applications, ensuring accurate detection of beta-1-syntrophin in diverse tissues.