SYNPO2L Antibody / Synaptopodin 2-like protein, 100 ug

SYNPO2L antibody detects Synaptopodin 2-like protein, an actin-binding cytoskeletal protein associated with cardiac and skeletal muscle structure and function. Encoded by the SYNPO2L gene on chromosome 10q22.2, this protein is part of the synaptopodin family and contributes to sarcomere organization, Z-disc stability, and myofibril assembly. SYNPO2L localizes to actin stress fibers and the Z-discs of cardiomyocytes, where it plays a key role in linking the actin cytoskeleton to contractile apparatus components.

Structurally, SYNPO2L contains actin-binding domains and proline-rich motifs that mediate interaction with alpha-actinin and other cytoskeletal proteins. It helps anchor signaling molecules at Z-discs, coordinating mechanical and biochemical responses during muscle contraction and adaptation. Through its role in actin filament organization, SYNPO2L contributes to cardiomyocyte differentiation and maintenance of sarcomere integrity.

The SYNPO2L antibody is widely used in cardiovascular and muscle research to study cytoskeletal architecture, myofibril assembly, and Z-disc organization. Western blot analysis detects a 110 kilodalton band corresponding to SYNPO2L, while immunofluorescence shows striated staining patterns characteristic of sarcomeric proteins. This antibody is valuable for investigating the molecular mechanisms of cardiac development, contractile regulation, and myopathy pathogenesis.

Genetic variants in SYNPO2L are associated with atrial fibrillation and cardiomyopathy, suggesting its importance in cardiac conduction and mechanical stability. Altered expression of SYNPO2L may also affect stress fiber organization in non-muscle cells, influencing cell migration and adhesion. The SYNPO2L antibody supports studies of muscle structure, cytoskeletal signaling, and heart disease mechanisms. NSJ Bioreagents provides this antibody validated for its applications, ensuring accuracy in studies of cytoskeletal and cardiac biology.