PLAGL2 Antibody / Pleiomorphic adenoma gene-like 2, 100 ug

PLAGL2 antibody detects Pleiomorphic adenoma gene-like protein 2, a zinc finger transcription factor involved in cell proliferation, differentiation, and tumorigenesis. Encoded by the PLAGL2 gene on chromosome 20q11.21, this nuclear protein belongs to the PLAG family of transcription factors, which regulate gene expression through DNA binding to consensus sequences within promoter regions. PLAGL2 is known for its dual role in promoting stem cell maintenance and activating oncogenic pathways, as well as influencing differentiation and apoptosis depending on cellular context.

Structurally, PLAGL2 contains seven C2H2-type zinc finger domains that enable DNA binding and transcriptional activation of target genes such as IGF2, PAI-1, and NRP1. It interacts with coactivators and chromatin remodeling proteins to modulate gene transcription linked to growth and migration. PLAGL2 contributes to the regulation of Wnt and hypoxia signaling pathways by activating genes involved in angiogenesis and metabolic adaptation.

The PLAGL2 antibody is widely used in cancer biology, developmental biology, and transcriptional regulation research to study gene activation and oncogenic signaling. Western blot analysis typically identifies a 57 kilodalton band corresponding to PLAGL2, while immunofluorescence shows nuclear localization consistent with its role as a transcriptional regulator. This antibody allows investigation of transcriptional networks and regulatory mechanisms controlling cellular transformation and differentiation.

In oncology, PLAGL2 has been implicated in colorectal, lung, and brain cancers where it promotes stem-like characteristics, epithelial-mesenchymal transition, and resistance to apoptosis. Conversely, in certain developmental contexts, PLAGL2 supports normal differentiation by activating lineage-specific genes. The PLAGL2 antibody provides a powerful tool for exploring these complex regulatory roles in tumor and stem cell biology. NSJ Bioreagents validates this antibody for its applications, ensuring dependable detection in transcriptional and cancer signaling studies.