SERPINA12 Antibody / Serpin A12 / Vaspin, 100 ug

SERPINA12 antibody detects Vaspin (serpin A12), a secreted serine protease inhibitor that modulates insulin sensitivity, inflammation, and metabolic balance. Encoded by the SERPINA12 gene on chromosome 14q32.13, this protein belongs to the serpin (serine protease inhibitor) superfamily, known for their roles in controlling proteolytic cascades. Vaspin is predominantly expressed in visceral adipose tissue, liver, and pancreas, and circulates as an adipokine that improves insulin sensitivity and exerts anti-inflammatory effects. Its expression is influenced by obesity, metabolic stress, and insulin signaling, suggesting a compensatory role in metabolic homeostasis.

SERPINA12 inhibits proteases that degrade insulin-sensitizing factors and inflammatory mediators, contributing to glucose regulation and vascular protection. Experimental models demonstrate that Vaspin administration improves glucose tolerance and reduces insulin resistance in obese and diabetic subjects. Mechanistically, it modulates serine protease activity in adipose tissue and the liver, attenuating inflammatory cytokine production and endothelial dysfunction. It may also interact with GRP78 on cell surfaces to activate downstream signaling that promotes insulin sensitivity and cellular protection.

The SERPINA12 antibody is widely used in endocrinology, metabolism, and cardiovascular research to study the regulation and function of Vaspin. Western blot analysis typically identifies a 45 kilodalton band corresponding to the unglycosylated form of the protein, while immunohistochemistry shows cytoplasmic and extracellular staining in adipose and hepatic tissues. This antibody supports investigation of the molecular mechanisms underlying insulin resistance, obesity, and metabolic inflammation.

Beyond metabolic regulation, SERPINA12 is associated with cardiovascular protection through inhibition of vascular inflammation and endothelial apoptosis. It may also have roles in tissue repair and cancer progression. NSJ Bioreagents provides the SERPINA12 antibody validated for its applications, ensuring accurate detection for metabolic and protease regulation studies.