CEBPG Antibody / CCAAT/enhancer-binding protein gamma, 100 ug

CEBPG antibody targets CCAAT/enhancer-binding protein gamma, a member of the CEBP family of transcription factors that regulate genes involved in immune response, metabolism, and cell differentiation. CEBPG lacks a canonical transactivation domain and instead acts as a dimerization partner for other CEBP family members such as CEBPA, CEBPB, and CEBPD, influencing transcription through heterodimer formation. This modulatory activity enables CEBPG to fine-tune expression of genes associated with inflammation, DNA repair, and oxidative stress responses. The protein is localized primarily in the nucleus, where it binds to CCAAT motifs within promoter regions and modulates transcriptional outcomes depending on its dimerization partner.

CEBPG is encoded by the CEBPG gene located on chromosome 19q13.11 and produces a protein of approximately 15 kilodaltons. It is ubiquitously expressed but particularly abundant in immune cells, liver, and lung tissues. Through interaction with CEBPB, CEBPG contributes to the regulation of cytokine expression, lipid metabolism, and acute phase responses. In addition to its transcriptional role, CEBPG has been linked to DNA damage tolerance pathways, where it may cooperate with ATF4 to activate antioxidant genes during cellular stress. The CEBPG antibody is therefore widely used in studies of transcriptional regulation, inflammation, and stress response signaling.

Research indicates that CEBPG participates in regulatory networks controlling macrophage activation and epithelial defense responses. Overexpression or silencing of CEBPG affects the expression of downstream effectors such as SOD2, GPX1, and TNF, linking this factor to redox balance and inflammatory signaling. Because of its cooperative interactions with other CEBP proteins, CEBPG serves as an important hub in transcriptional cascades influencing differentiation and immune adaptation. The CEBPG antibody is validated for western blotting, immunofluorescence, and chromatin immunoprecipitation assays, enabling analysis of protein expression and DNA-binding activity. NSJ Bioreagents provides this antibody for researchers studying gene regulation, stress adaptation, and cellular defense mechanisms.