NETO1 Antibody / Neuropilin and tolloid-like protein 1, 100 ug

NETO1 antibody detects Neuropilin and tolloid-like protein 1, a neuronal transmembrane glycoprotein that modulates ionotropic glutamate receptor function and synaptic plasticity. NETO1 acts as an auxiliary subunit of kainate-type glutamate receptors (KARs), regulating receptor trafficking, channel gating, and synaptic localization. The NETO1 antibody is widely used in neurobiology and synaptic physiology to study excitatory neurotransmission and learning mechanisms.

NETO1 is encoded by the NETO1 gene located on human chromosome 18q22.1. The protein is approximately 533 amino acids long and contains two extracellular CUB domains, a low-density lipoprotein receptor-like domain, a single transmembrane helix, and a short cytoplasmic tail. NETO1 is predominantly expressed in the hippocampus, cortex, and cerebellum, where it localizes to postsynaptic membranes and interacts with KAR subunits such as GluK2 and GluK5.

The NETO1 antibody detects a 63 kilodalton protein by western blot and shows punctate synaptic staining in neurons. NETO1 enhances the stability and functional diversity of KARs by modulating desensitization kinetics and surface expression. It contributes to long-term potentiation and synaptic scaling, processes underlying memory and learning. Mice lacking NETO1 display deficits in synaptic plasticity and spatial learning, confirming its critical role in excitatory neurotransmission.

Beyond the brain, NETO1 may participate in developmental signaling and axonal growth. Dysregulation or mutation of NETO1 has been associated with autism spectrum disorder, schizophrenia, and cognitive impairment. By shaping receptor signaling and synaptic strength, NETO1 maintains proper excitatory balance within neural circuits.

As a neuron-specific regulatory subunit of kainate receptors, NETO1 is a key molecule for studying excitatory synaptic physiology and plasticity. NSJ Bioreagents provides a validated NETO1 antibody optimized for its applications, supporting research into neurotransmission, synaptic regulation, and neurological disorders.