DTNB Antibody / Dystrobrevin beta, 100 ug

DTNB antibody detects Dystrobrevin beta, a cytoplasmic scaffolding protein that associates with dystrophin and syntrophin complexes at the plasma membrane. DTNB participates in maintaining membrane stability, signal transduction, and cytoskeletal anchoring in muscle and neuronal tissues. The DTNB antibody is widely used in muscle biology, neuroscience, and membrane research to study dystrophin-associated complexes and neuromuscular organization.

DTNB is encoded by the DTNB gene located on human chromosome 2p16.2. The protein is approximately 628 amino acids in length and shares structural similarity with dystrobrevin alpha. DTNB localizes to the cytoplasmic face of the sarcolemma and interacts with dystrophin, syntrophins, and other adaptor proteins within the dystrophin-glycoprotein complex (DGC), which links the cytoskeleton to the extracellular matrix.

The DTNB antibody detects a 70 kilodalton protein by western blot and reveals sarcolemmal and cytoplasmic localization under immunofluorescence microscopy. In skeletal muscle, DTNB contributes to stabilization of muscle fibers and transmission of mechanical force. In neurons, it participates in postsynaptic density organization and signal transduction, influencing synaptic plasticity and neurotransmission.

Dysfunction or loss of DTNB disrupts DGC integrity, leading to impaired muscle contractility and signaling abnormalities. Variants in DTNB have been associated with neuromuscular diseases, cognitive deficits, and cardiomyopathy. Through its scaffolding functions, DTNB regulates localization of signaling molecules such as nitric oxide synthase and kinases involved in muscle adaptation.

Because of its role in linking the cytoskeleton to membrane signaling complexes, DTNB provides insights into muscular dystrophy mechanisms and synaptic organization. NSJ Bioreagents provides a validated DTNB antibody optimized for its applications, supporting research into muscle integrity, neuronal communication, and cytoskeletal scaffolding.