OAT1 Antibody / Organic anion transporter 1 / SLC22A6, 100 ug

OAT1 antibody detects Organic anion transporter 1, a renal membrane transporter responsible for the uptake of a wide range of endogenous metabolites and xenobiotics. OAT1 plays a vital role in drug excretion, toxin clearance, and metabolic waste handling. The OAT1 antibody is used in nephrology, pharmacology, and toxicology research to study renal secretion, drug-drug interactions, and kidney function.

OAT1 is encoded by the SLC22A6 gene located on human chromosome 11q12.3. The protein is approximately 563 amino acids long and belongs to the solute carrier 22 family. OAT1 is expressed predominantly in the basolateral membrane of renal proximal tubule cells, where it mediates the uptake of organic anions from the bloodstream into tubular cells, enabling their secretion into urine via apical transporters.

The OAT1 antibody detects a 60 kilodalton band by western blot and shows basolateral membrane staining in kidney tissue sections. OAT1 transports metabolites such as urate, prostaglandins, and p-aminohippurate, as well as drugs including antivirals, diuretics, and antibiotics. Its activity depends on the transmembrane exchange of alpha-ketoglutarate, coupling organic anion uptake to cellular metabolism.

Because OAT1 handles many pharmaceuticals, it is a major determinant of drug pharmacokinetics and toxicity. Inhibition or saturation of OAT1 can lead to altered drug clearance and nephrotoxicity. Genetic polymorphisms in OAT1 affect drug response variability and susceptibility to renal injury. Beyond renal physiology, OAT1 contributes to organic acid homeostasis in the brain and choroid plexus.

By regulating solute movement between blood and urine, OAT1 maintains chemical balance and metabolic detoxification. NSJ Bioreagents provides a validated OAT1 antibody optimized for its applications, supporting research into kidney physiology, drug metabolism, and transporter-mediated toxicity.