Osmr Antibody / Oncostatin M receptor, 100 ug

OSMR antibody detects Oncostatin M receptor, a cytokine receptor that forms part of the type I cytokine receptor family and mediates signaling by the cytokines oncostatin M and interleukin-31. OSMR dimerizes with either gp130 or IL31RA to initiate downstream JAK-STAT, MAPK, and PI3K signaling cascades. The OSMR antibody is widely used in immunology, inflammation, and cancer research to study cytokine signaling, tissue remodeling, and immune regulation.

OSMR is encoded by the OSMR gene on human chromosome 5p13.1. The protein is approximately 100 kilodaltons and contains an extracellular cytokine-binding domain, a single transmembrane helix, and a cytoplasmic tail harboring signaling motifs that recruit JAK kinases and STAT transcription factors. OSMR is expressed in a wide range of cell types, including epithelial cells, fibroblasts, and immune cells, where it mediates diverse biological responses to inflammatory cues.

An OSMR antibody detects a 100-200 kilodalton band by western blot and exhibits membrane and perinuclear staining under immunofluorescence. Ligand binding induces heterodimerization of OSMR with gp130 or IL31RA, leading to phosphorylation of JAK1 and JAK2 and subsequent activation of STAT3 and STAT5 transcription factors. These pathways regulate genes involved in cell proliferation, differentiation, and extracellular matrix remodeling.

In the immune system, OSMR signaling modulates macrophage activation, Th2 cytokine production, and inflammation resolution. In epithelial tissues, OSMR promotes wound healing and regeneration but, when overactivated, contributes to chronic inflammation and fibrosis. Dysregulation of OSMR expression has been linked to psoriasis, asthma, and several cancers, where it enhances tumor progression through paracrine cytokine signaling.

Because of its dual role in inflammation and tissue regeneration, OSMR represents an important biomarker and therapeutic target in immune-mediated and neoplastic diseases. NSJ Bioreagents provides a validated OSMR antibody optimized for its applications, supporting research into cytokine receptor signaling, inflammatory pathways, and cancer biology.