PSMA6 Antibody / Proteasome subunit alpha type 6, 100 ug

PSMA6 antibody detects Proteasome subunit alpha type-6, a core component of the 20S proteasome complex responsible for ATP-dependent protein degradation. PSMA6 contributes to the structural organization of the proteasome's alpha ring, which controls access to the catalytic chamber that degrades misfolded, oxidized, or regulatory proteins. The PSMA6 antibody is used in studies of proteostasis, ubiquitin signaling, and stress response pathways.

PSMA6 is encoded by the PSMA6 gene located on human chromosome 14q13.2. The protein is approximately 27 kilodaltons and forms one of seven alpha subunits that compose the outer rings of the cylindrical 20S core particle. Together with beta subunits, these structures assemble into the functional 26S proteasome when associated with regulatory particles such as PA700 or PA28. PSMA6 is critical for maintaining proteolytic efficiency and specificity by regulating substrate entry and gate opening.

The PSMA6 antibody detects a 27 kilodalton protein by western blot and reveals strong cytoplasmic and nuclear staining, consistent with proteasome distribution. PSMA6 contributes to the degradation of short-lived proteins involved in cell cycle progression, apoptosis, and signal transduction. Through the ubiquitin-proteasome system (UPS), PSMA6 supports protein quality control and adaptive responses to oxidative or metabolic stress.

Mutations or altered expression of PSMA6 have been linked to cardiovascular and autoimmune diseases, as well as cancer. Overexpression in tumors enhances proteasomal activity and supports rapid cell proliferation, while reduced expression leads to accumulation of damaged proteins and cellular dysfunction. In immune cells, PSMA6 influences antigen processing and presentation, shaping adaptive immune responses.

Because of its fundamental role in protein degradation, PSMA6 serves as a biomarker for proteasome activity and a potential target for therapeutic intervention in cancer and neurodegenerative diseases. NSJ Bioreagents provides a validated PSMA6 antibody optimized for western blot, immunocytochemistry, and proteasome complex studies, supporting detailed analysis of cellular protein turnover and homeostasis regulation.