GAS2L2 Antibody / Growth arrest-specific protein 2-like 2, 100 ug

GAS2L2 antibody detects Growth arrest-specific protein 2-like 2, a cytoskeletal-associated protein that links microtubules and actin filaments. GAS2L2 contributes to cell shape maintenance, mechanical stability, and tissue organization. The GAS2L2 antibody is used to study cytoskeleton interactions, cell polarity, and epithelial morphogenesis.

GAS2L2 is encoded by the GAS2L2 gene on human chromosome 17p13.1. The protein is approximately 97 kilodaltons and contains a calponin homology (CH) domain that binds actin and a GAS2-related (GAR) domain that associates with microtubules. This dual-binding capability enables GAS2L2 to coordinate actin-microtubule crosslinking, influencing cell architecture and mechanotransduction.

The GAS2L2 antibody reveals filamentous and junctional staining in epithelial and smooth muscle cells. GAS2L2 expression is enriched in respiratory and reproductive epithelia, where it stabilizes apical cell-cell contacts. Loss of GAS2L2 disrupts ciliogenesis and planar cell polarity, leading to impaired epithelial alignment and fluid transport. In fibroblasts and neurons, GAS2L2 contributes to microtubule organization and axonal guidance.

Beyond structural support, GAS2L2 regulates cell migration and wound healing by modulating actin polymerization dynamics. It interacts with signaling proteins that respond to mechanical stress, suggesting a role in tissue homeostasis and mechanosensitive pathways. Mutations or altered expression of GAS2L2 are associated with ciliary dysfunction and airway remodeling disorders.

Because of its crosslinking function, GAS2L2 serves as a molecular bridge between cytoskeletal networks, coordinating force generation and cellular tension. NSJ Bioreagents provides a validated GAS2L2 antibody, supporting research into epithelial organization, mechanical signaling, and cell polarity regulation.