OSBPL5 Antibody / Oxysterol-binding protein-related protein 5, 100 ug

OSBPL5 antibody detects Oxysterol-binding protein-related protein 5, a lipid transfer protein involved in cholesterol and phospholipid exchange between organelles. OSBPL5 belongs to the oxysterol-binding protein (OSBP) family that mediates lipid homeostasis and endoplasmic reticulum-plasma membrane tethering. The OSBPL5 antibody is used in studies of lipid metabolism, organelle communication, and membrane dynamics.

OSBPL5 is encoded by the OSBPL5 gene located on human chromosome 11q13.1. The protein is approximately 100 kilodaltons and contains a pleckstrin homology (PH) domain, a FFAT motif, and a C-terminal OSBP-like sterol-binding domain. OSBPL5 localizes to membrane contact sites between the endoplasmic reticulum and late endosomes or mitochondria, where it regulates non-vesicular lipid transport.

The OSBPL5 antibody detects a 100 kilodalton band on western blot and exhibits punctate cytoplasmic staining. Functional studies show that OSBPL5 participates in cholesterol redistribution and phosphatidylserine transport, thereby influencing membrane composition and signaling. It also regulates autophagy and mitochondrial dynamics by modulating lipid exchange at organelle interfaces.

OSBPL5 plays roles in metabolism, growth regulation, and reproduction, with high expression in liver, testis, and brain. Dysregulation has been linked to metabolic disorders, including insulin resistance and obesity. NSJ Bioreagents provides a validated OSBPL5 antibody, supporting research into lipid trafficking, membrane homeostasis, and organelle interaction.