SPON1 Antibody / Spondin 1, 100 ug

SPON1 antibody detects Spondin-1, an extracellular matrix protein that promotes cell adhesion, axon guidance, and tissue organization. Spondin-1 is a member of the F-spondin family of secreted glycoproteins that regulate neuronal outgrowth and vascular patterning. The SPON1 antibody is used in neuroscience, developmental biology, and vascular research to study ECM signaling and neural development.

SPON1 is encoded by the SPON1 gene located on human chromosome 11p15.2. The protein is approximately 91 kilodaltons and consists of a signal peptide, reelin domain, thrombospondin type I repeats, and a C-terminal region that mediates cell surface binding. Spondin-1 is secreted into the extracellular matrix where it interacts with integrins and heparan sulfate proteoglycans to promote neurite extension and cell attachment.

A SPON1 antibody can detect a 90-95 kilodalton band by western blot and reveals extracellular and pericellular staining in immunohistochemistry. During embryonic development, Spondin-1 guides commissural axons across the midline and contributes to axonal fasciculation. In adult tissues, it participates in vascular remodeling and ECM integrity. Spondin-1 is also implicated in Alzheimer's disease pathology, where altered expression affects amyloid precursor protein processing.

Beyond neural function, Spondin-1 contributes to chondrogenesis, osteogenesis, and tumor angiogenesis. Its expression is upregulated during wound repair and inflammation, suggesting a role in tissue regeneration. NSJ Bioreagents provides a validated SPON1 antibody, supporting investigations into neuronal growth and extracellular signaling.