METTL17 Antibody / Methyltransferase-like protein 17, 100 ug

METTL17 antibody detects Methyltransferase-like protein 17, a mitochondrial RNA methyltransferase that contributes to the biogenesis and function of mitochondrial ribosomes. METTL17 catalyzes methylation of specific rRNA nucleotides, a process essential for proper ribosomal assembly and translational fidelity within mitochondria. This enzyme is part of the large family of S-adenosylmethionine-dependent methyltransferases, many of which regulate gene expression and RNA stability. The METTL17 antibody is widely used to study mitochondrial gene expression, translation, and the broader methyltransferase network involved in RNA modification and energy metabolism.

METTL17 is encoded by the METTL17 gene located on human chromosome 11q24.2. The protein localizes primarily to the mitochondrial matrix, where it associates with mitochondrial ribosomal subunits. Structurally, METTL17 contains a conserved Rossmann-like fold typical of class I methyltransferases, which facilitates binding to S-adenosyl-L-methionine (SAM), the universal methyl donor. Loss of METTL17 function impairs mitochondrial translation, leading to reduced oxidative phosphorylation and energy production.

The METTL17 antibody is useful in identifying both endogenous and overexpressed protein in cell lysates. Western blot typically reveals a single band around 44�46 kDa corresponding to full-length METTL17. Immunofluorescence analysis demonstrates mitochondrial localization with co-staining of mitochondrial markers such as TOM20 or COX IV. Functional studies have shown that METTL17 interacts with mitochondrial ribosomal RNA and components of the large ribosomal subunit, supporting its role in rRNA modification and mitoribosome assembly.

Defects in METTL17-mediated methylation have been linked to disrupted mitochondrial respiration and altered cellular energy metabolism. In addition to its mitochondrial functions, METTL17 expression has been observed in proliferating cells and certain cancer tissues, suggesting potential links between RNA methylation and tumor metabolism. NSJ Bioreagents provides a validated METTL17 antibody for western blot, immunofluorescence, and immunoprecipitation applications, enabling detailed characterization of mitochondrial RNA processing and the effects of METTL17 on bioenergetics and translation regulation.