GLOD4 Antibody / Glyoxalase domain-containing protein 4, 100 ug

GLOD4 antibody detects Glyoxalase domain-containing protein 4, encoded by the GLOD4 gene on chromosome 17q25.3. GLOD4 antibody is widely applied in metabolism, detoxification, and mitochondrial biology research. Although GLOD4's precise enzymatic role remains incompletely defined, it contains homology to glyoxalase enzymes, which detoxify reactive dicarbonyls such as methylglyoxal, a byproduct of glycolysis.

Structurally, GLOD4 is a ~36 kDa protein with a glyoxalase-like fold. It is predicted to bind metal ions that assist catalysis, though definitive enzymatic activity has yet to be confirmed. Localization studies suggest enrichment in mitochondria, highlighting a role in redox balance and metabolic regulation.

Functionally, GLOD4 may protect cells from glycation stress by metabolizing reactive aldehydes. Its expression is broad, with higher levels in metabolic tissues such as liver, kidney, and muscle. Researchers use GLOD4 antibody to study mitochondrial metabolism, detoxification pathways, and oxidative stress responses.

Clinically, altered GLOD4 expression has been observed in cancer and metabolic disease. By influencing redox balance, GLOD4 may contribute to tumor survival under stress conditions. It is under investigation as a metabolic biomarker and therapeutic target. NSJ Bioreagents provides GLOD4 antibody for metabolic, mitochondrial, and cancer research.

Experimentally, GLOD4 antibody is applied in western blotting to detect the ~36 kDa protein, in immunofluorescence microscopy to study mitochondrial localization, and in immunohistochemistry to assess expression across tissues. Functional studies combining GLOD4 antibody with metabolic assays help clarify its enzymatic role in glyoxalase pathways.