SNX20 Antibody / Sorting nexin 20, 100 ug

SNX20 antibody detects Sorting nexin-20, encoded by the SNX20 gene on chromosome 17p13.1. SNX20 antibody is widely used in studies of vesicular trafficking, endocytosis, and immune regulation. SNX20 belongs to the sorting nexin family, a group of proteins involved in endosomal sorting, membrane trafficking, and signal transduction. These proteins share a conserved PX domain that binds phosphoinositides and targets them to endosomal membranes.

Structurally, SNX20 is a ~37 kDa protein containing a phox homology (PX) domain and a long coiled-coil region. This domain architecture allows membrane binding and protein-protein interactions that drive endosomal sorting. Unlike some sorting nexins, SNX20 lacks a BAR domain, suggesting its primary function is cargo recognition and endosomal signaling rather than membrane tubulation.

Functionally, SNX20 regulates trafficking of membrane proteins from early endosomes to recycling or degradation pathways. It has been implicated in controlling receptor turnover, modulating immune receptor signaling, and maintaining endosomal organization. Researchers use SNX20 antibody to study intracellular trafficking and receptor regulation in immune cells and other tissues.

Clinically, SNX20 dysregulation has been linked to inflammatory bowel disease, gastric cancer, and lung cancer. Altered expression may affect immune receptor localization and tumor progression. Because endosomal trafficking influences many signaling pathways, SNX20 is a candidate biomarker and therapeutic target. NSJ Bioreagents provides SNX20 antibody to support studies of vesicular trafficking, immunity, and cancer.

Experimentally, SNX20 antibody is used in western blotting to detect the ~37 kDa protein, in immunofluorescence microscopy to assess endosomal localization, and in immunohistochemistry to study expression in tissues. Co-immunoprecipitation with SNX20 antibody identifies trafficking partners and cargo proteins.