MAMDC4 Antibody / MAM domain-containing protein 4, 100 ug

MAMDC4 antibody detects MAM domain-containing protein 4, encoded by the MAMDC4 gene on chromosome 9q34.3. MAMDC4 antibody is commonly used in cell adhesion, signaling, and developmental biology research. MAMDC4 is a transmembrane glycoprotein characterized by the presence of MAM domains (meprin, A5, mu), which mediate cell adhesion and protein-protein interactions. Although its precise functions are not fully defined, MAMDC4 is thought to participate in epithelial integrity, neuronal development, and cell signaling.

Structurally, MAMDC4 is a 104-131 kDa protein with multiple MAM domains, immunoglobulin-like domains, and a single transmembrane segment. These structural motifs are shared with proteins involved in cell adhesion and neural guidance. MAMDC4 localizes to the plasma membrane and may be secreted in some contexts. Expression is enriched in epithelial tissues and developing nervous system.

Functionally, MAMDC4 contributes to cell-cell interactions, adhesion, and extracellular signaling. Its MAM domains mediate protein binding that influences cellular communication and tissue organization. Researchers use MAMDC4 antibody to study epithelial biology, neurodevelopment, and signaling networks.

Clinically, MAMDC4 has been implicated in cancer progression, particularly in colorectal and gastric cancers, where altered expression correlates with invasion and metastasis. Variants in MAMDC4 may also influence susceptibility to developmental disorders and neurological disease, though further research is needed. NSJ Bioreagents provides MAMDC4 antibody to support studies of adhesion, signaling, and disease biology.

Experimentally, MAMDC4 antibody is used in western blotting to detect the 104-131 kDa protein, in immunohistochemistry to analyze epithelial expression, and in immunofluorescence microscopy to visualize membrane localization. Co-immunoprecipitation with MAMDC4 antibody helps identify adhesion and signaling partners.