NSUN6 Antibody / NOP2/Sun RNA methyltransferase family member 6, 100 ug

NSUN6 antibody detects NOP2/Sun RNA methyltransferase family member 6, encoded by the NSUN6 gene on chromosome 10q22.1. NSUN6 antibody is widely used in RNA biology, epigenetics, and cancer research. NSUN6 belongs to the RNA cytosine methyltransferase family, catalyzing site-specific methylation of cytosine residues in tRNAs and possibly other RNAs. This modification, known as 5-methylcytosine, influences RNA stability, structure, and function.

Structurally, NSUN6 is a ~55 kDa cytoplasmic protein containing an RNA recognition motif and a conserved catalytic domain typical of cytosine-5 methyltransferases. It selectively modifies tRNAs at position C72 in the acceptor stem, a modification critical for efficient aminoacylation and translation. NSUN6 localizes predominantly in the cytoplasm but may also act in the nucleus under certain conditions.

Functionally, NSUN6 promotes translation fidelity and efficiency by stabilizing tRNA structure. It contributes to cellular stress responses, growth, and differentiation. Altered NSUN6 activity disrupts RNA modifications, impacting protein synthesis and cellular homeostasis. Researchers use NSUN6 antibody to study RNA epigenetics, translation control, and stress biology.

Clinically, dysregulation of RNA methyltransferases including NSUN6 is implicated in cancer, neurodevelopmental disorders, and viral infections. NSUN6 overexpression has been linked to certain tumors, suggesting a role in tumor growth. Conversely, loss-of-function may impair translation and stress adaptation. Because RNA modifications are emerging therapeutic targets, NSUN6 is an attractive focus for research. NSJ Bioreagents supplies NSUN6 antibody for epigenetics, cancer, and RNA biology studies.

Experimentally, NSUN6 antibody is applied in western blotting to detect the ~55 kDa protein, in immunofluorescence microscopy to visualize cytoplasmic distribution, and in RNA immunoprecipitation to map RNA substrates. Co-immunoprecipitation with NSUN6 antibody identifies protein partners in RNA methylation complexes.