EDNRB Antibody / Endothelin receptor type B, 100 ug

EDNRB antibody detects Endothelin receptor type B, encoded by the EDNRB gene on chromosome 13q22.3. EDNRB antibody is commonly used in vascular biology, developmental biology, and oncology. EDNRB is a G protein-coupled receptor (GPCR) for endothelins, which are potent vasoactive peptides regulating vascular tone, cell proliferation, and migration. EDNRB plays essential roles in cardiovascular development, neural crest cell migration, and gastrointestinal innervation.

Structurally, EDNRB is a ~45 kDa protein with seven transmembrane helices characteristic of GPCRs. It couples to G proteins to activate intracellular signaling cascades, including phospholipase C, MAPK, and calcium mobilization pathways. EDNRB binds endothelins 1, 2, and 3, with particularly high affinity for endothelin-3. Expression is found in endothelial cells, smooth muscle, melanocytes, and enteric neurons.

Functionally, EDNRB regulates vasodilation and vasoconstriction, contributes to melanocyte development, and guides neural crest migration. In the gastrointestinal tract, EDNRB signaling supports formation of the enteric nervous system. Loss of EDNRB function impairs neural crest cell survival and migration, leading to developmental abnormalities. Researchers use EDNRB antibody to study GPCR signaling, vascular biology, and neurodevelopment.

Clinically, mutations in EDNRB cause Hirschsprung disease and Waardenburg syndrome type IV, both involving neural crest defects. Dysregulated EDNRB expression is also linked to melanoma and other cancers, where it promotes proliferation and invasion. Because endothelin signaling influences vascular remodeling, EDNRB is studied in pulmonary hypertension and cardiovascular disease. NSJ Bioreagents provides EDNRB antibody to support vascular biology, developmental genetics, and oncology research.

Experimentally, EDNRB antibody is used in western blotting to detect the ~45 kDa receptor, in immunohistochemistry to study expression in vascular and neural tissues, and in immunofluorescence to examine GPCR localization. Co-immunoprecipitation with EDNRB antibody helps identify receptor complexes and signaling partners.