HTATSF1 Antibody / HIV Tat-specific factor 1, 100 ug

HTATSF1 antibody detects HIV Tat-specific factor 1, encoded by the HTATSF1 gene on chromosome 17q21.31. HTATSF1 antibody is commonly used in transcription biology, RNA processing, and viral research. HTATSF1 was originally identified as a cellular factor required for HIV-1 Tat-mediated transcriptional activation. It is now recognized as a general transcription elongation factor that associates with RNA polymerase II and influences RNA splicing, elongation, and processing.

Structurally, HTATSF1 is a nuclear protein containing RS-rich domains typical of splicing regulators, as well as multiple motifs for protein-protein and protein-RNA interactions. These domains allow HTATSF1 to associate with the transcription machinery and with spliceosomal components. Isoforms generated by alternative splicing may modulate transcriptional and splicing activities.

Functionally, HTATSF1 facilitates RNA polymerase II elongation by interacting with transcriptional elongation complexes and splicing factors. It coordinates co-transcriptional splicing, ensuring efficient coupling of RNA synthesis with processing. In the context of HIV infection, HTATSF1 enhances Tat-dependent transcriptional elongation, supporting viral replication. Researchers use HTATSF1 antibody to study transcription elongation, splicing regulation, and viral-host interactions.

Clinically, dysregulation of HTATSF1 has been implicated in cancer, where altered transcription elongation contributes to oncogenic gene expression. Because transcription elongation is critical for rapidly dividing cells, HTATSF1 is considered a potential therapeutic target. HTATSF1 also influences viral replication and could serve as a target for antiviral therapies. NSJ Bioreagents provides HTATSF1 antibody to support research in transcription biology, RNA processing, and infectious disease.

Experimentally, HTATSF1 antibody is used in western blotting to detect the protein, in immunohistochemistry to examine nuclear expression in tissues, and in chromatin immunoprecipitation to analyze transcriptional elongation complexes. Co-immunoprecipitation with HTATSF1 antibody identifies interaction partners in the elongation and splicing machinery.