NRTN Antibody / Neurturin, 100 ug

NRTN antibody detects Neurturin, encoded by the NRTN gene on chromosome 19p13.3. NRTN antibody is widely used in neuroscience, developmental biology, and neurodegeneration studies. Neurturin is a secreted growth factor of the glial cell line-derived neurotrophic factor (GDNF) family, which supports survival and maintenance of neurons. It plays roles in peripheral nervous system development, innervation of target tissues, and maintenance of dopaminergic neurons.

Structurally, Neurturin is a ~20 kDa secreted protein with a cystine-knot motif characteristic of the TGF-beta superfamily. It is synthesized as a precursor with a signal peptide and pro-region that is cleaved to yield the mature form. Neurturin binds to the GFRalpha-2 receptor, which complexes with RET tyrosine kinase to initiate downstream signaling cascades, including MAPK and PI3K-Akt pathways.

Functionally, Neurturin promotes survival of parasympathetic, sensory, and dopaminergic neurons. It enhances axonal outgrowth, synaptic maintenance, and neuronal regeneration after injury. Researchers use NRTN antibody to investigate neurotrophic signaling, neuron survival, and therapies for neurodegenerative diseases.

Clinically, Neurturin has been investigated for therapeutic potential in Parkinson's disease, where delivery of recombinant Neurturin aims to protect and restore dopaminergic neurons. Altered NRTN expression is linked to gastrointestinal innervation defects and autonomic dysfunction. Because of its restricted receptor usage, Neurturin has selective effects compared to other GDNF family members. NSJ Bioreagents offers NRTN antibody for studies of neuroprotection, development, and disease models.

Experimentally, NRTN antibody is used in western blotting to detect the ~20 kDa protein, in immunohistochemistry to study expression in neural and peripheral tissues, and in ELISA to quantify secreted protein in conditioned media. Co-immunoprecipitation with NRTN antibody identifies binding partners including GFRalpha-2 and RET.