FAM111B Antibody / Serine protease FAM111B, 100 ug

FAM111B antibody detects Serine protease FAM111B, encoded by the FAM111B gene on chromosome 11q12.1. FAM111B antibody is used in research on DNA replication, cell cycle regulation, and genetic disease. FAM111B is a serine protease-like protein that interacts with DNA replication machinery, where it regulates chromatin accessibility and replication progression. Expression is broad across tissues, with enrichment in proliferating cells, consistent with its cell cycle roles.

Structurally, FAM111B is a ~75 kDa protein containing a trypsin-like serine protease domain, though the catalytic activity remains incompletely defined. It also features domains mediating chromatin association and interactions with replication factors. Alternative splicing produces isoforms with potentially distinct regulatory functions.

Functionally, FAM111B contributes to DNA replication by regulating replisome assembly and progression. It also appears to restrict viral replication, consistent with emerging roles in antiviral defense. Knockdown of FAM111B causes replication stress, chromatin instability, and impaired cell proliferation. Researchers use FAM111B antibody to investigate DNA replication, chromatin biology, and cell cycle control.

Clinically, mutations in FAM111B cause hereditary fibrosing poikiloderma, a multisystem disorder characterized by fibrosis, skin abnormalities, and increased cancer risk. These mutations often occur in the protease-like domain, altering protein stability and function. FAM111B has also been implicated in cancer, where altered expression contributes to tumorigenesis and response to therapy. As DNA replication is a critical process in cancer cells, FAM111B represents a potential therapeutic target. NSJ Bioreagents supplies FAM111B antibody for genetic disease, cancer, and replication biology research.

Experimentally, FAM111B antibody is used in western blotting to detect the ~85 kDa protein, in immunofluorescence to assess nuclear localization, and in immunohistochemistry to analyze tissue expression. Co-immunoprecipitation with FAM111B antibody identifies replication factors and chromatin-associated proteins.