NLRP6 Antibody / NALP6, 100 ug

NLRP6 antibody detects NLR family pyrin domain-containing protein 6, encoded by the NLRP6 gene on chromosome 11p15.4. NLRP6 antibody is widely used to study innate immunity, inflammasome biology, and gut homeostasis. NLRP6 belongs to the Nod-like receptor (NLR) family, which detects microbial components and danger signals in the cytoplasm. It forms an inflammasome complex with ASC and caspase-1, leading to activation of IL-1b and IL-18. NLRP6 is highly expressed in intestinal epithelial cells, liver, and immune cells, positioning it as a critical regulator of mucosal defense and inflammation.

Structurally, NLRP6 contains an N-terminal pyrin domain (PYD), a central nucleotide-binding domain (NACHT), and C-terminal leucine-rich repeats (LRRs). The PYD interacts with ASC, enabling inflammasome assembly, while the NACHT domain mediates oligomerization and ATP-dependent activation. These structural motifs are conserved across the NLR family and ensure proper inflammasome formation in response to stimuli.

Functionally, NLRP6 contributes to host defense and microbiota regulation. It mediates inflammasome activation, resulting in caspase-1 activation and processing of IL-1b and IL-18. NLRP6 also regulates secretion of antimicrobial peptides and maintains intestinal barrier integrity. Deficiency of NLRP6 leads to altered gut microbiota composition, increased susceptibility to colitis, and impaired clearance of pathogens. Researchers use NLRP6 antibody to investigate inflammasome biology, gut-immune interactions, and host defense mechanisms.

Clinically, NLRP6 is associated with inflammatory diseases, infection, and cancer. Reduced NLRP6 expression is linked to inflammatory bowel disease, including Crohn's disease and ulcerative colitis. Dysregulation also contributes to liver diseases such as steatohepatitis. In cancer, NLRP6 has context-dependent roles, either promoting tumor suppression by maintaining homeostasis or contributing to tumorigenesis through chronic inflammation. NSJ Bioreagents offers NLRP6 antibody for studies in immunology, microbiology, and inflammation biology.

Experimentally, NLRP6 antibody is applied in western blotting to detect the ~103 kDa protein, in immunohistochemistry to study gut and liver expression, and in immunofluorescence microscopy to visualize inflammasome assembly. Immunoprecipitation with NLRP6 antibody enables isolation of inflammasome complexes for mechanistic analysis.