METTL26 Antibody / Methyltransferase-like protein 26, 100 ug

METTL26 antibody detects Methyltransferase-like protein 26, encoded by the METTL26 gene on chromosome 16p13.3. METTL26 antibody is used to investigate this putative methyltransferase that belongs to the large METTL family of proteins. Although its biochemical activity is less defined compared to other METTL members, METTL26 is thought to participate in RNA modification, epigenetic regulation, and potentially protein methylation. Expression has been reported in many tissues, with enrichment in brain and reproductive tissues, suggesting specialized roles in gene regulation and development.

Structurally, METTL26 contains an S-adenosylmethionine (SAM)-binding domain characteristic of methyltransferases. This domain is predicted to catalyze methyl group transfer, though specific substrates remain unidentified. Comparative analyses suggest METTL26 may have diverged to acquire unique functions in RNA processing or chromatin regulation. The protein may act as a scaffold in ribonucleoprotein complexes, linking methylation activity to RNA stability and translation.

Functionally, METTL26 is implicated in gene expression regulation. RNA-seq data show METTL26 knockdown affects expression of genes involved in cell cycle and RNA metabolism. Although its enzymatic targets are unknown, METTL26 may contribute to post-transcriptional regulation through RNA modification. Some studies suggest potential roles in splicing and small RNA pathways. Researchers apply METTL26 antibody to investigate these emerging functions in RNA biology and epigenetics.

Clinically, METTL26 remains underexplored, but methyltransferase-like proteins are increasingly associated with cancer, neurological disease, and developmental disorders. Given its expression in brain and reproductive tissues, METTL26 may influence neuronal differentiation, gametogenesis, or embryonic development. Its genomic location on 16p13.3 also makes it a candidate for involvement in congenital syndromes with deletions in this region. NSJ Bioreagents provides METTL26 antibody as a high-quality reagent to support the growing field of methyltransferase biology.

Experimentally, METTL26 antibody is used in western blotting to detect the ~30 kDa protein, in immunohistochemistry to evaluate tissue distribution, and in immunofluorescence microscopy to study subcellular localization. Immunoprecipitation with METTL26 antibody may help identify binding partners and clarify its biological role. These studies will help establish its significance in RNA processing and epigenetic control.