SUCO Antibody / SUN domain containing ossification factor, 100 ug

SUCO antibody detects SUN domain containing ossification factor, encoded by the SUCO gene. SUN domain containing ossification factor is a nuclear envelope-associated protein that contributes to bone development, nuclear architecture, and gene regulation. SUCO antibody provides researchers with a tool for studying skeletal biology, nuclear envelope function, and developmental disorders.

SUN domain containing ossification factor belongs to a protein family characterized by SUN domains, which interact with KASH domain proteins to form linker complexes across the nuclear envelope. Research using SUCO antibody has shown that it is expressed in bone and cartilage tissue, where it regulates ossification and skeletal patterning. Its role in nuclear envelope organization suggests that SUCO coordinates cytoskeletal forces with transcriptional regulation during skeletal development.

Studies with SUCO antibody have revealed that variants in the SUCO gene are associated with congenital skeletal abnormalities, including delayed ossification and craniofacial defects. These phenotypes underscore its developmental importance and highlight the need for further exploration of its molecular functions. Beyond skeletal biology, SUCO may also regulate chromatin positioning and nuclear stability, although these functions remain under investigation.

Dysregulation of SUN domain containing ossification factor has been linked to both bone disease and broader nuclear envelope disorders. Research using SUCO antibody has demonstrated that altered SUCO expression influences osteoblast differentiation and bone mineralization. Because of its nuclear positioning, SUCO may also influence responses to mechanical stress in musculoskeletal tissue.

SUCO antibody is widely applied in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry demonstrates expression in bone and cartilage tissue, western blotting quantifies protein levels across developmental stages, and immunofluorescence highlights nuclear envelope localization. These approaches make SUCO antibody valuable in skeletal and nuclear envelope research.

By supplying validated SUCO antibody reagents, NSJ Bioreagents supports studies into ossification, nuclear architecture, and disease. Detection of SUN domain containing ossification factor provides researchers with insight into how nuclear proteins regulate skeletal development and pathology.