PHLDB3 Antibody / Pleckstrin homology-like domain family B member 3, 100 ug

PHLDB3 antibody detects Pleckstrin homology-like domain family B member 3, encoded by the PHLDB3 gene. Pleckstrin homology-like domain family B member 3 is a cytoplasmic protein involved in signaling regulation, p53 modulation, and cancer biology. PHLDB3 antibody provides researchers with a specific reagent for studying cell survival, apoptosis, and tumorigenesis.

Pleckstrin homology-like domain family B member 3 contains a pleckstrin homology-like domain that mediates interactions with membranes and signaling proteins. Research using PHLDB3 antibody has shown that it regulates p53 stability and transcriptional activity. By promoting degradation of p53, PHLDB3 influences cell cycle control and survival, positioning it as an important factor in tumor progression.

Studies with PHLDB3 antibody have revealed that its expression is upregulated in certain cancers, including colon and breast cancers. Elevated expression correlates with reduced p53 function and enhanced proliferation, linking PHLDB3 to oncogenic pathways. Conversely, depletion of PHLDB3 enhances apoptosis and impairs tumor growth, suggesting its therapeutic potential.

In addition to cancer, PHLDB3 may participate in normal cellular signaling. Research using PHLDB3 antibody has suggested roles in insulin signaling and metabolic regulation, although these functions remain under investigation. Its pleckstrin homology-like domain suggests a role in membrane recruitment and signaling scaffolding.

PHLDB3 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in tumors and cell lines, immunohistochemistry demonstrates localization in tissue sections, and immunofluorescence highlights cytoplasmic distribution. These approaches make PHLDB3 antibody valuable in signaling and cancer research.

By providing validated PHLDB3 antibody reagents, NSJ Bioreagents supports studies into apoptosis, p53 regulation, and tumor biology. Detection of Pleckstrin homology-like domain family B member 3 provides researchers with insight into how signaling proteins modulate survival pathways and cancer progression.