NCOA2 Antibody / Nuclear receptor coactivator 2, 100 ug

NCOA2 antibody detects Nuclear receptor coactivator 2, encoded by the NCOA2 gene. Nuclear receptor coactivator 2 is a transcriptional coactivator that interacts with nuclear hormone receptors and enhances their transcriptional activity. NCOA2 antibody provides researchers with a valuable reagent for studying gene regulation, endocrine signaling, and cancer biology.

Nuclear receptor coactivator 2, also called SRC2 or GRIP1, belongs to the p160 family of coactivators. Research using NCOA2 antibody has shown that it interacts with estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and peroxisome proliferator-activated receptor. By recruiting histone acetyltransferases and chromatin remodeling complexes, NCOA2 promotes transcriptional activation in response to hormones and ligands.

Studies with NCOA2 antibody have revealed that it is widely expressed in endocrine tissues, brain, and muscle. Its ability to act as a transcriptional scaffold allows integration of multiple signaling inputs, fine-tuning transcriptional responses. This makes NCOA2 central to metabolism, reproduction, and development.

Dysregulation of NCOA2 has been linked to endocrine disorders and cancer. Research using NCOA2 antibody has shown that chromosomal translocations involving NCOA2 occur in acute lymphoblastic leukemia and mesenchymal tumors. Overexpression has also been observed in prostate and breast cancers, where NCOA2 enhances oncogenic signaling. These findings underscore its importance as a biomarker and potential therapeutic target.

NCOA2 antibody is widely used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies nuclear receptor binding sites, western blotting quantifies coactivator expression, and immunohistochemistry demonstrates nuclear localization in hormone-responsive tissues. These methods make NCOA2 antibody essential for transcription and cancer research.

By providing validated NCOA2 antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, hormone signaling, and oncogenesis. Detection of Nuclear receptor coactivator 2 provides researchers with insight into how nuclear coactivators integrate signaling pathways and control gene expression.