RAB27B Antibody / Ras related protein Rab-27B, 100 ug

RAB27B antibody detects Ras related protein Rab-27B, encoded by the RAB27B gene. Ras related protein Rab-27B is a member of the Rab family of small GTP binding proteins that regulate vesicle trafficking, secretion, and membrane transport. RAB27B antibody provides researchers with a highly specific reagent for studying secretory pathways, exocytosis, and disease processes involving vesicle transport.

Ras related protein Rab-27B localizes to secretory granules and vesicles, where it regulates docking and fusion events. Research using RAB27B antibody has shown that it interacts with effectors such as Munc13-4 and Slac2 proteins, coordinating tethering and priming of vesicles prior to exocytosis. This function is critical for regulated secretion in endocrine, neuronal, and immune cells.

Studies with RAB27B antibody have demonstrated that it plays a role in exocytosis of lysosome-related organelles, platelet dense granules, and lytic granules of cytotoxic T cells. By coordinating vesicle release, Rab-27B contributes to hormone secretion, platelet function, and immune responses. These findings highlight its broad physiological roles in vesicle biology.

Dysregulation of Ras related protein Rab-27B has been associated with cancer and neurological disease. Research using RAB27B antibody has shown that overexpression promotes secretion of growth factors and extracellular vesicles in cancers such as breast and gastric cancer, supporting invasion and metastasis. Variants in RAB27B also influence susceptibility to neurological disorders, where altered secretion affects neuronal communication.

RAB27B antibody is widely applied in immunofluorescence, western blotting, and immunohistochemistry. Immunofluorescence demonstrates vesicular localization, western blotting quantifies expression levels, and immunohistochemistry reveals tissue-specific distribution. These applications make RAB27B antibody indispensable for vesicle trafficking research.

By supplying validated RAB27B antibody reagents, NSJ Bioreagents supports studies into exocytosis, vesicle trafficking, and disease. Detection of Ras related protein Rab-27B provides researchers with insight into how Rab GTPases regulate secretion and intercellular communication.