NDUFA9 Antibody / NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, 100 ug

NDUFA9 antibody detects NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, encoded by the NDUFA9 gene. NADH dehydrogenase 1 alpha subcomplex subunit 9 is an accessory component of mitochondrial complex I, the first and largest enzyme of the oxidative phosphorylation pathway. NDUFA9 antibody provides researchers with a useful reagent for studying mitochondrial respiration, electron transport, and energy metabolism.

Complex I catalyzes the transfer of electrons from NADH to ubiquinone, driving proton pumping across the inner mitochondrial membrane. Research using NDUFA9 antibody has shown that NADH dehydrogenase 1 alpha subcomplex subunit 9 is essential for the structural integrity and stability of the complex, though it does not directly participate in electron transfer. This accessory function ensures efficient oxidative phosphorylation and ATP production.

Studies with NDUFA9 antibody have demonstrated that loss or dysfunction of NDUFA9 destabilizes complex I, leading to impaired electron transport and reduced ATP output. This disruption contributes to mitochondrial disorders characterized by neuromuscular dysfunction, lactic acidosis, and neurodegeneration. NDUFA9 mutations have been identified in patients with Leigh syndrome and other mitochondrial diseases.

In addition to inherited disorders, altered expression of NDUFA9 has been observed in cancer. Research using NDUFA9 antibody has revealed that tumor cells often reprogram mitochondrial function, and changes in NDUFA9 expression reflect altered bioenergetics. Reduced expression has also been linked to susceptibility to oxidative stress and apoptosis, highlighting its importance in both physiology and disease.

NDUFA9 antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression in mitochondrial fractions, immunohistochemistry localizes protein in energy-demanding tissues such as heart and brain, and immunofluorescence demonstrates mitochondrial distribution. These applications make NDUFA9 antibody indispensable in mitochondrial biology research.

By providing validated NDUFA9 antibody reagents, NSJ Bioreagents supports studies into oxidative phosphorylation, bioenergetics, and disease. Detection of NADH dehydrogenase 1 alpha subcomplex subunit 9 provides researchers with insights into how mitochondrial accessory proteins stabilize respiratory chain complexes.