NSJ Bioreagents
SKU:F50381-0.08ML
AMPK alpha 2 Antibody / PRKAA2, 0.08ml
AMPK alpha 2 Antibody / PRKAA2, 0.08ml
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The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Specifications
| Catalog No | F50381-0.08ML |
|---|---|
| Family | Primary antibody |
| Qty | 0.08ml |
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Predicted Species Reactivity | Mouse,Rat |
| Application | WB, IHC, ELISA |
| Application Details | Western blot: 1:1000,IHC (Paraffin): 1:10-1:50 |
| Application Note | Titration of the AMPK alpha 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Status | Available |
| PDF Link | Product Data Sheet (PDF) |
| Limitation | This AMPK alpha 2 antibody is available for research use only. |
| Uniprot # | P54646 |
| Purity | Purified |
| Immunogen | A portion of amino acids 453-483 from the human protein was used as the immunogen for this AMPK alpha 2 antibody. |
| Storage | Aliquot the AMPK alpha 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Title | AMPK alpha 2 Antibody / PRKAA2 |
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