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NSJ Bioreagents
SKU:F48579-0.08ML
MDM2 Antibody (pS395), 0.08ml
MDM2 Antibody (pS395), 0.08ml
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MDM2 is a target of the transcription factor tumor protein p53. This protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. MDM2 also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
Specifications
| Catalog No | F48579-0.08ML |
|---|---|
| Family | Primary antibody |
| Qty | 0.08ml |
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | DB, ELISA |
| Application Details | Dot blot: 1:500 |
| Application Note | Titration of the phospho-MDM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Status | Available |
| PDF Link | Product Data Sheet (PDF) |
| Limitation | This phospho-MDM2 antibody is available for research use only. |
| Uniprot # | Q00987 |
| Purity | Antigen affinity |
| Immunogen | This phospho-MDM2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS395 of human MDM2. |
| Storage | Aliquot the phospho-MDM2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Title | MDM2 Antibody (pS395) |
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