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NSJ Bioreagents
SKU:F54950-0.08ML
Cytochrome P450 3A5 Antibody / CYP3A5
Cytochrome P450 3A5 Antibody / CYP3A5
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CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB, IF, IHC-P |
| Application Details | Western blot: 1:500-1:1000, Immunofluorescence: 1:10-1:50, Immunohistochemistry (FFPE): 1:10-1:50 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the Cytochrome P450 3A5 antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 476-502 from the human protein was used as the immunogen for the Cytochrome P450 3A5 antibody. |
| Purity | Purified |
| Storage | Aliquot the Cytochrome P450 3A5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This Cytochrome P450 3A5 antibody is available for research use only. |
| Uniprot # | P20815 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cytochrome-p450-3a5-antibody-cyp3a5-f54950 |
| Title | Cytochrome P450 3A5 Antibody / CYP3A5 |
| Description | CYP3A5 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. |
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