NSJ Bioreagents
SKU:RQ7473
CVAK104 Antibody / SCYL2
CVAK104 Antibody / SCYL2
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SCY1-like protein 2, also called Coated vesicle-associated kinase of 104 kDa and CVAK104, is a protein that in humans is encoded by the SCYL2 gene. The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB, IF, FACS, Direct ELISA |
| Application Details | Western blot: 0.5-1ug/ml,Immunofluorescence: 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml |
| Application Note | Optimal dilution of the CVAK104 antibody should be determined by the researcher. |
| Localization | Cytoplasmic |
| Immunogen | E. coli-derived recombinant human protein (amino acids E208-Q909) was used as the immunogen for the CVAK104 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the CVAK104 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This CVAK104 antibody is available for research use only. |
| Uniprot # | Q6P3W7 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cvak104-antibody-scyl2-rq7473 |
| Title | CVAK104 Antibody / SCYL2 |
| Description | SCY1-like protein 2, also called Coated vesicle-associated kinase of 104 kDa and CVAK104, is a protein that in humans is encoded by the SCYL2 gene. The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. |
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