• Western blot testing of rat 1) brain, 2) spleen, 3) heart, 4) kidney and mouse 5) brain, 6) spleen, 7) heart, 8) kidney and 9) testis lysate with Cullin 5 antibody at 0.5ug/ml. Predicted molecular weight ~91 kDa.
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NSJ Bioreagents

RQ4333

Cullin 5 Antibody / CUL5

Cullin 5 Antibody / CUL5

$449.00 USD
$449.00 USD
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Cullin-5 is a protein that in humans is encoded by the CUL5 gene. Cul5 inhibits cellular proliferation, potentially through its involvement in the SOCS/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the ubiquitin system for protein degradation. One study have shown that Cul5 plays a role in Reelin signaling cascade, participating in the DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.

Specifications

Family Primary antibody
Formulation 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format Antigen affinity purified
Host Animal Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Species Reactivity Human, Mouse, Rat
Application WB, ELISA
Application Details Western blot: 0.5-1ug/ml, Direct ELISA: 0.1-0.5ug/ml (human recombinant protein)
Application Note Optimal dilution of the Cullin 5 antibody should be determined by the researcher.
Immunogen A recombinant human protein corresponding to amino acids A2-D105 was used as the immunogen for the Cullin 5 antibody.
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Purity Antigen affinity purified
Storage After reconstitution, the Cullin 5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitation This Cullin 5 antibody is available for research use only.
Uniprot # Q93034
Status Available
PDF Link https://www.nsjbio.com/tds-pdf/cullin-5-antibody-cul5-rq4333
Title Cullin 5 Antibody / CUL5
Description Cullin-5 is a protein that in humans is encoded by the CUL5 gene. Cul5 inhibits cellular proliferation, potentially through its involvement in the SOCS/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the ubiquitin system for protein degradation. One study have shown that Cul5 plays a role in Reelin signaling cascade, participating in the DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.
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