• Western blot testing of human 1) HeLa, 2) COLO-320, 3) MDA-MB-231, 4) Jurkat and 5) PANC-1 cell lysate with CUL4A antibody at 0.5ug/ml. Predicted molecular weight ~88 kDa.
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NSJ Bioreagents

RQ4317

CUL4A Antibody

CUL4A Antibody

$449.00 USD
$449.00 USD
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Cullin-4A is a protein that in humans is encoded by the CUL4A gene. It belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. Interestingly, a component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.

Specifications

Family Primary antibody
Formulation 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format Antigen affinity purified
Host Animal Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Species Reactivity Human, Mouse, Rat
Application WB, ELISA
Application Details Western blot: 0.5-1ug/ml, Direct ELISA: 0.1-0.5ug/ml
Application Note Optimal dilution of the CUL4A antibody should be determined by the researcher.
Immunogen A recombinant human protein corresponding to amino acids M494-A759 was used as the immunogen for the CUL4A antibody.
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Purity Antigen affinity purified
Storage After reconstitution, the CUL4A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitation This CUL4A antibody is available for research use only.
Uniprot # Q13619
Status Available
PDF Link https://www.nsjbio.com/tds-pdf/cul4a-antibody-rq4317
Title CUL4A Antibody
Description Cullin-4A is a protein that in humans is encoded by the CUL4A gene. It belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. Interestingly, a component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.
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