• Western blot testing of 1) human HepG2, 2) human HCCT, 3) human HCCP and 4) mouse liver tissue lysate with CTSL antibody. Expected molecular weight: 38-41 kDa with multiple smaller processed/active forms.
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NSJ Bioreagents

RQ6857

CTSL Antibody / Cathepsin L

CTSL Antibody / Cathepsin L

$449.00 USD
$449.00 USD
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The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.

Specifications

Family Primary antibody
Formulation 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Format Antigen affinity purified
Host Animal Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Species Reactivity Human, Mouse
Application WB
Application Details Western blot: 1-2ug/ml
Application Note Optimal dilution of the CTSL antibody should be determined by the researcher.
Immunogen Amino acids EATEESCKYNPKYSVAND from the human protein were used as the immunogen for the CTSL antibody.
Buffer Lyophilized from 1X PBS with 2% Trehalose
Purity Antigen affinity purified
Storage After reconstitution, the CTSL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitation This CTSL antibody is available for research use only.
Uniprot # P07711
Status Available
PDF Link https://www.nsjbio.com/tds-pdf/ctsl-antibody-cathepsin-l-rq6857
Title CTSL Antibody / Cathepsin L
Description The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell.
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