NSJ Bioreagents
SKU:RQ7974
CRMP2 Antibody / DPYSL2
CRMP2 Antibody / DPYSL2
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Dihydropyrimidinase-related protein 2, also called Collapsin response mediator protein 2 (CRMP2), is an enzyme that in humans is encoded by the DPYSL2 gene. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human, Mouse, Rat |
| Application | WB, IF |
| Application Details | Western blot: 0.5-1ug/ml,Immunofluorescence: 5ug/ml |
| Application Note | Optimal dilution of the CRMP2 antibody should be determined by the researcher. |
| Localization | Cytoplasmic, cell membrane |
| Immunogen | Amio acids KDRFQLTDCQIYEVLSV were used as the immunogen for the CRMP2 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the CRMP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This CRMP2 antibody is available for research use only. |
| Uniprot # | Q16555 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/crmp2-antibody-dpysl2-rq7974 |
| Title | CRMP2 Antibody / DPYSL2 |
| Description | Dihydropyrimidinase-related protein 2, also called Collapsin response mediator protein 2 (CRMP2), is an enzyme that in humans is encoded by the DPYSL2 gene. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
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