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NSJ Bioreagents
SKU:F55075-0.08ML
CrkRS Antibody / CDK12 / Cyclin-dependent kinase 12
CrkRS Antibody / CDK12 / Cyclin-dependent kinase 12
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$205.00 USD
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CrkRS, also known as Cdc2-related kinase, arginine/serine-rich, CDK12 and Cyclin-dependent kinase 12, is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. It also regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human, Mouse |
| Application | WB |
| Application Details | Western blot: 1:500-1:1000 |
| Application Note | Titration of the CrkRS antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 1-30 from the human protein was used as the immunogen for this CrkRS antibody. |
| Storage | Aliquot the CrkRS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CrkRS antibody is available for research use only. |
| Uniprot # | Q9NYV4 |
| Status | Available |
| PDF Link | http://www.nsjbio.com/tds-pdf/crkrs-antibody-cdk12-cyclin-dependent-kinase-12-f55075 |
| Title | CrkRS Antibody / CDK12 / Cyclin-dependent kinase 12 |
| Description | CrkRS, also known as Cdc2-related kinase, arginine/serine-rich, CDK12 and Cyclin-dependent kinase 12, is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. It also regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. |
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