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NSJ Bioreagents
SKU:RQ7731
Crk-like protein Antibody / CrkL
Crk-like protein Antibody / CrkL
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Crk-like protein is a protein that in humans is encoded by the CRKL gene. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB, IF, FACS, IP, Direct ELISA |
| Application Details | Western blot: 0.5-1ug/ml,Immunofluorescence: 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml,Immunoprecipitation: 2ug per 500ug of lysate |
| Application Note | Optimal dilution of the Crk-like protein antibody should be determined by the researcher. |
| Localization | Cytoplasmic, nuclear |
| Immunogen | E. coli-derived recombinant human protein (amino acids M1-H290) was used as the immunogen for the Crk-like protein antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| Purity | Antigen affinity purified |
| Storage | After reconstitution, the Crk-like protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Crk-like protein antibody is available for research use only. |
| Uniprot # | P46109 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/crk-like-protein-antibody-crkl-rq7731 |
| Title | Crk-like protein Antibody / CrkL |
| Description | Crk-like protein is a protein that in humans is encoded by the CRKL gene. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. |
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