NSJ Bioreagents
SKU:F55077-0.08ML
CRCL Antibody / Calcitonin receptor-like receptor
CRCL Antibody / Calcitonin receptor-like receptor
Couldn't load pickup availability
CRCL, also called CALCRL and Calcitonin gene-related peptide type 1 receptor, is a member of the G-protein coupled receptor (GPCR) family, a group of proteins that play a key role in transmitting signals from the outside of the cell to the inside. Specifically, CRCL is known for its involvement in regulating the activity of a neuropeptide called calcitonin gene-related peptide (CGRP), which is involved in pain transmission, migraine development, and vasodilation. CRCL plays a crucial role in mediating the effects of CGRP on various cellular processes. When CGRP binds to CRCL, it triggers a series of signaling cascades that ultimately lead to changes in cell function. For example, activation of CRCL by CGRP can lead to vasodilation in blood vessels, modulation of pain perception, and regulation of inflammatory responses. Dysregulation of this protein has been implicated in various diseases. Abnormalities in CRCL signaling have been linked to migraine development, chronic pain conditions, and cardiovascular diseases.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | WB, IHC-P |
| Application Details | Western blot: 1:1000-1:2000,Immunohistochemistry: 1:100-1:500 |
| Application Note | Titration of the CRCL antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Immunogen | A portion of amino acids 340-367 from the human protein was used as the immunogen for this CRCL antibody. |
| Storage | Aliquot the CRCL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CRCL antibody is available for research use only. |
| Uniprot # | Q16602 |
| Status | Available |
| PDF Link | http://www.nsjbio.com/tds-pdf/crcl-antibody-calcitonin-receptor-like-receptor-f55077 |
| Title | CRCL Antibody / Calcitonin receptor-like receptor |
| Description | CRCL, also called CALCRL and Calcitonin gene-related peptide type 1 receptor, is a member of the G-protein coupled receptor (GPCR) family, a group of proteins that play a key role in transmitting signals from the outside of the cell to the inside. Specifically, CRCL is known for its involvement in regulating the activity of a neuropeptide called calcitonin gene-related peptide (CGRP), which is involved in pain transmission, migraine development, and vasodilation. CRCL plays a crucial role in mediating the effects of CGRP on various cellular processes. When CGRP binds to CRCL, it triggers a series of signaling cascades that ultimately lead to changes in cell function. For example, activation of CRCL by CGRP can lead to vasodilation in blood vessels, modulation of pain perception, and regulation of inflammatory responses. Dysregulation of this protein has been implicated in various diseases. Abnormalities in CRCL signaling have been linked to migraine development, chronic pain conditions, and cardiovascular diseases. |
Share
