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NSJ Bioreagents
SKU:R36477-100UG
CNGB3 Antibody
CNGB3 Antibody
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$475.00 USD
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Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Cyclic nucleotide-gated cation channel beta-3 can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [UniProt]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide |
| Format | Antigen affinity purified |
| Host Animal | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Species Reactivity | Human |
| Application | IHC-P, ELISA (peptide) |
| Application Details | IHC (FFPE): 2-4ug/ml,ELISA (peptide) LOD: 1:8000 |
| Application Note | Optimal dilution of the CNGB3 antibody should be determined by the researcher. |
| Immunogen | Amino acids ESDDKPTEHYYR were used as the immunogen for this CNGB3 antibody. |
| Purity | Antigen affinity |
| Storage | Aliquot and store the CNGB3 antibody at -20oC. |
| Limitation | This CNGB3 antibody is available for research use only. |
| Uniprot # | Q9NQW8 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cngb3-antibody-r36477 |
| Title | CNGB3 Antibody |
| Description | Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. Cyclic nucleotide-gated cation channel beta-3 can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [UniProt] |
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