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NSJ Bioreagents
SKU:F54612-0.08ML
CMGA Antibody / Chromogranin A
CMGA Antibody / Chromogranin A
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The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | In 1X PBS, pH 7.4, with 0.09% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Species Reactivity | Human |
| Application | FACS, IF, IHC-P, WB |
| Application Details | Flow cytometry: 1:25 (1x10e6 cells), Immunofluorescence: 1:25, Immunohistochemistry (FFPE): 1:25, Western blot: 1:500-1:2000 |
| Application Note | The stated application concentrations are suggested starting points. Titration of the CMGA antibody may be required due to differences in protocols and secondary/substrate sensitivity. |
| Localization | Cytoplasmic |
| Immunogen | A portion of amino acids 376-404 from the human protein was used as the immunogen for the CMGA antibody. |
| Purity | Antigen affinity purified |
| Storage | Aliquot the CMGA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CMGA antibody is available for research use only. |
| Uniprot # | P10645 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/cmga-antibody-chromogranin-a-f54612 |
| Title | CMGA Antibody / Chromogranin A |
| Description | The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. |
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