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NSJ Bioreagents
SKU:N1092-25UG
CLEC1 Antibody
CLEC1 Antibody
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$225.00 USD
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CLEC1 is a C-type lectin receptor and part of the ‘Dectin-1 cluster’ subfamily which also includes Dectin-1, LOX-1, CLEC-2, MICL, CLEC12B, and CLEC9A. Similar to other family members, CLEC1 displays N-liked glycosylation and dimerization characteristics, and is found on dendritic cells, monocytes and granulocytes. However, unlike other family members, CLEC1 expression level is upregulated by IL-10 and TGFb, but not by pro-inflammatory stimuli, and it is expressed on endothelial cells. Enhanced expression at allograft sites suggests CLEC1 may have an immune-regulatory function and may support allograft tolerance.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Format | Purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB |
| Application Details | Western blot: 2-5ug/ml |
| Application Note | Provided assay concentrations are suggestions only, CLEC1 antibody titration may be required for optimal results. |
| Immunogen | A recombinant protein fragment from the N-terminal portin of human CLEC1 was used as the immunogen for this antibody. |
| Buffer | 1X PBS, pH 7.4 |
| Purity | Protein A purified antibody |
| Storage | Aliquot the CLEC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles. |
| Limitation | This CLEC1 antibody is available for research use only. |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/clec1-antibody-n1092 |
| Title | CLEC1 Antibody |
| Description | CLEC1 is a C-type lectin receptor and part of the ‘Dectin-1 cluster’ subfamily which also includes Dectin-1, LOX-1, CLEC-2, MICL, CLEC12B, and CLEC9A. Similar to other family members, CLEC1 displays N-liked glycosylation and dimerization characteristics, and is found on dendritic cells, monocytes and granulocytes. However, unlike other family members, CLEC1 expression level is upregulated by IL-10 and TGFb, but not by pro-inflammatory stimuli, and it is expressed on endothelial cells. Enhanced expression at allograft sites suggests CLEC1 may have an immune-regulatory function and may support allograft tolerance. |
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