• IHC analysis of FFPE human hepatocarcinoma tissue stained with Claudin 2 antibody
  • Immunofluorescent staining of FFPE human Caco-2 cells with Claudin 2 antibody (green) and DAPI nuclear stain (blue). HIER: steam section in pH6 citrate buffer for 20 min.
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NSJ Bioreagents

F49580-0.08ML

Claudin 2 Antibody (CLDN2)

Claudin 2 Antibody (CLDN2)

$205.00 USD
$205.00 USD
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Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in the protein have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in CLDN2 lacking cells leads to increase of permeability for small cations. Furthermore, CLDN2 has been shown to form paracellular channels for water. [Wiki]

Specifications

Family Primary antibody
Formulation In 1X PBS, pH 7.4, with 0.09% sodium azide
Format Antigen affinity purified
Host Animal Rabbit
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Species Reactivity Human
Predicted Species Reactivity Bovine, Mouse
Application WB, IHC, ELISA
Application Details Western blot: 1:1000,IHC (Paraffin): 1:10-1:50
Application Note Titration of the Claudin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Immunogen A portion of amino acids 135-164 from the human protein was used as the immunogen for this Claudin 2 antibody.
Purity Antigen affinity
Storage Aliquot the Claudin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitation This Claudin 2 antibody is available for research use only.
Uniprot # P57739
Status Available
PDF Link https://www.nsjbio.com/tds-pdf/claudin-2-antibody-cldn2-f49580
Title Claudin 2 Antibody (CLDN2)
Description Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in the protein have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in CLDN2 lacking cells leads to increase of permeability for small cations. Furthermore, CLDN2 has been shown to form paracellular channels for water. [Wiki]
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