NSJ Bioreagents
SKU:RQ5712
Claudin 1 Antibody / CLDN1
Claudin 1 Antibody / CLDN1
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Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | 0.5mg/ml if reconstituted with 0.2ml sterile DI water |
| Format | Antigen affinity purified |
| Host Animal | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | IHC-P, IF |
| Application Details | Immunohistochemistry (FFPE): 1-2ug/ml,Immunofluorescence: 2-4ug/ml |
| Application Note | Optimal dilution of the Claudin 1 antibody should be determined by the researcher. |
| Localization | Cytoplasmic |
| Immunogen | Amino acids ATAWYGNRIVQEFYD from the human protein were used as the immunogen for the Claudin 1 antibody. |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| Purity | Affinity purified |
| Storage | After reconstitution, the Claudin 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing. |
| Limitation | This Claudin 1 antibody is available for research use only. |
| Uniprot # | O95832 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/claudin-1-antibody-cldn1-rq5712 |
| Title | Claudin 1 Antibody / CLDN1 |
| Description | Claudin-1 is a protein that in humans is encoded by the CLDN1 gene. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. |
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