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NSJ Bioreagents
SKU:RQ4709
CHEK1 Antibody / CHK1
CHEK1 Antibody / CHK1
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The protein encoded by CHEK1 belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. [RefSeq]
Specifications
| Family | Primary antibody |
|---|---|
| Formulation | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA |
| Format | Purified |
| Clone | EIB-3 |
| Host Animal | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Species Reactivity | Human |
| Application | WB |
| Application Details | Western blot: 1:500-1:2000 |
| Application Note | Optimal dilution of the CHEK1 antibody should be determined by the researcher. |
| Immunogen | A synthetic peptide specific to human CHK1 / CHEK1 was used as the immunogen for the CHEK1 antibody. |
| Purity | Affinity purified |
| Storage | Store the CHEK1 antibody at -20oC. |
| Limitation | This CHEK1 antibody is available for research use only. |
| Uniprot # | O14757 |
| Status | Available |
| PDF Link | https://www.nsjbio.com/tds-pdf/chek1-antibody-chk1-eib-3-rq4709 |
| Title | CHEK1 Antibody / CHK1 |
| Description | The protein encoded by CHEK1 belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. [RefSeq] |
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